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This effect appears to be driven by anti-inflammatory and proliferative mechanisms independent of receptor activation/signaling in the resident vascular cells [74,75,76]
J Cell Mol Med 23:25832594
In that way, headache improvement might not only be a consequence of weight loss but also another direct effect of GLP-1-RAs on intracranial pressure [15], which seems to be directly associated with MHD and headache severity [30]
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